The most common side effects of Protonix are headache, diarrhea, nausea, abdominal pain, vomiting, gas, dizziness, and joint pain. Common side effects of Nexium include headache, diarrhea, nausea, gas, abdominal pain, constipation, and dry mouth. Serious side effects of PPIs are often associated with long-term use.
Serious side effects may include osteoporosis-related bone fractures, vitamin B12 deficiency, and low magnesium levels hypomagnesemia. Frequency is not based on data from a head-to-head trial. This may not be a complete list of adverse effects that can occur. Please refer to your doctor or healthcare provider to learn more. Protonix and Nexium, like other PPIs, interact with many of the same medications.
These PPIs should be monitored or avoided with other drugs that are dependent on stomach acidity for absorption. Drugs that are dependent on stomach acidity for absorption include iron salts, erlotinib, ketoconazole, and mycophenolate mofetil. Protonix and Nexium can also interact with antiretroviral drugs, or drugs that are often used to treat HIV.
PPIs can increase or decrease blood levels of antiretroviral drugs, which can lead to an increased risk of toxicity or decreased effectiveness with antiretroviral drugs. Nexium should be monitored or avoided with diazepam since it can increase blood levels of diazepam and lead to an increased risk of adverse effects.
The use of Nexium and clopidogrel together should also be avoided. Nexium can decrease how well clopidogrel works in the body, which can increase the risk of blood clots.
The long-term use of PPIs may lead to an increased risk of bone fractures, especially in people who have already been diagnosed with osteoporosis. Bone mineral density may need to be monitored during long-term treatment with PPIs. Some patients have experienced acute tubulointerstitial nephritis TIN while taking Protonix or Nexium.
Nephritis is the inflammation of the kidneys, which can lead to decreased kidney function. The use of PPIs may be linked to an increased risk of Clostridium difficile-associated diarrhea. Those who experience persistent diarrhea may need to be monitored, especially in a hospital setting. Taking Protonix or Nexium can increase the risk of low blood levels of magnesium hypomagnesemia or vitamin B12 vitamin B12 deficiency.
There is an increased risk of hypomagnesemia and vitamin B12 deficiency in those on long-term treatment with PPIs. Consult your healthcare provider for other possible warnings and precautions before taking a PPI. Protonix is available as a delayed-release tablet and liquid suspension. The generic name of Protonix is pantoprazole. It is available with a prescription or over the counter. Nexium primarily comes as a delayed-release capsule or a liquid suspension.
The generic name of Nexium is esomeprazole. However, they contain different active ingredients and come in different formulations.
This means that levels of the drug are higher in your bloodstream, and that esomeprazole may decrease acid production for a longer period of time. It may also work slightly faster to treat your symptoms compared to omeprazole. Esomeprazole is also broken down differently by your liver, so it may lead to fewer drug interactions than omeprazole. Some studies indicate that the differences between omeprazole and esomeprazole may offer some advantages to people with certain conditions.
An older study from found that esomeprazole provided more effective control of GERD than omeprazole at the same doses. According to a later study in , esomeprazole offered faster relief than omeprazole in the first week of use. After one week, symptom relief was similar. They cited concerns such as:. The authors analyzed 41 studies on the effectiveness of PPIs. Until March , Nexium was available only by prescription and at a significantly higher price.
However, generic omeprazole may be less expensive than Prilosec OTC. Work with your doctor or pharmacist to decide which PPI is best for you. In addition to cost, consider things like:. A link to possible dementia risk was reported in , but a larger confirmatory study in determined that there was no increased risk of dementia from using PPIs.
Many people experience excess acid production when they stop using PPIs. At the end of the recommended treatment duration, you should taper off of the medication gradually.
Work with your doctor to do so. Before taking either medication, talk to your doctor to learn about the risk factors and drug interactions associated with them. Always tell your doctor about all the drugs, herbs, and vitamins you take. Prilosec and Nexium can interact with other medications you might be taking. The U. Food and Drug Administration FDA has issued a warning that the drug in Prilosec reduces the effectiveness of the blood thinner clopidogrel Plavix.
Other drugs can interact with Nexium or Prilosec, but may still be taken with either drug. Tell your doctor if you take any of these drugs so they can evaluate your risk:. Lifestyle changes should be your first steps in controlling GERD and heartburn. You may want to try:. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor. It is important to take this medication exactly as prescribed by your doctor.
If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule.
Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice. Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children. Do not dispose of medications in wastewater e.
Ask your pharmacist how to dispose of medications that are no longer needed or have expired. Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.
The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor. Many of these side effects can be managed, and some may go away on their own over time.
Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects. Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention. Stop taking the medication and seek immediate medical attention if any of the following occur:. Some people may experience side effects other than those listed.
Check with your doctor if you notice any symptom that worries you while you are taking this medication. Before you begin taking a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health.
These factors may affect how you should take this medication. Diarrhea: When gastric acid is decreased, the number of bacteria normally in the digestive system increases. Occasionally, this can cause serious infection in the digestive tract.
If you experience watery, foul-smelling bowel movements after starting to take rabeprazole, contact your doctor as soon as possible. Liver function: Liver disease or reduced liver function may cause this medication to build up in the body, causing side effects.
If you have liver problems, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Magnesium levels: Rabeprazole may rarely cause low magnesium levels in people who take this medication for a prolonged period of time. Low magnesium may occur after at least 3 months, but usually after a year of treatment. If you have low magnesium levels in your blood, you should discuss with your doctor about how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Methotrexate interaction: Rabeprazole, like other medications in this group, may interact with methotrexate when the two medications are used at the same time. This combination may lead to higher than expected amounts of methotrexate in the body and can cause serious side effects, including kidney damage, irregular heartbeat, anemia, or infection.
If you take rabeprazole, and are also going to receive a dose of methotrexate, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
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